Motorists planning to use the 401 should expect delays.
Lennox and Addington OPP report that shortly after 3:30 p.m. a number of collisions occurred on both the eastbound and westbound lanes of the 401.
A collision occurred on 401 westbound, east of Brandon Creek and west of County Road 4 involving a tractor trailer, a pickup truck hauling a trailer and two cars.
A separate tractor trailer jackknifed across both of the westbound lanes.
The 401 westbound is closed and the emergency detour route is in place.
Vehicles must exit at County Road 4, to County Road 2 west to Palace Road and north on Palace Road to enter back on 401.
Four people have been taken to hospital with minor injuries.